Human Kallikrein 7 (KLK7) activation kit by CRISPRa

CAT#: GA103829

KLK7 CRISPRa kit - CRISPR gene activation of human kallikrein related peptidase 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLK7
• Locus ID: 5650
• Kit Components:

  GA103829G1, Kallikrein 7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103829G2, Kallikrein 7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103829G3, Kallikrein 7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001207053, NM_001243126, NM_005046, NM_139277
• Synonyms: hK7; PRSS6; SCCE
• Summary: 'This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]'