Human Proteasome subunit alpha type 6 (PSMA6) activation kit by CRISPRa

CAT#: GA103856

PSMA6 CRISPRa kit - CRISPR gene activation of human proteasome subunit alpha 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PSMA6
• Locus ID: 5687
• Kit Components:

  GA103856G1, Proteasome subunit alpha type 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103856G2, Proteasome subunit alpha type 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103856G3, Proteasome subunit alpha type 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282232, NM_001282233, NM_001282234, NM_002791, NR_104110
• Synonyms: IOTA; p27K; PROS27
• Summary: 'The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]'