Human Peptide YY (PYY) activation kit by CRISPRa

CAT#: GA103866

PYY CRISPRa kit - CRISPR gene activation of human peptide YY

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PYY
• Locus ID: 5697
• Kit Components:

  GA103866G1, Peptide YY gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103866G2, Peptide YY gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103866G3, Peptide YY gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004160
• Synonyms: PYY-I; PYY1
• Summary: 'This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]'