Human TAS2R38 activation kit by CRISPRa

CAT#: GA103892

TAS2R38 CRISPRa kit - CRISPR gene activation of human taste 2 receptor member 38

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TAS2R38
• Locus ID: 5726
• Kit Components:

  GA103892G1, TAS2R38 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103892G2, TAS2R38 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103892G3, TAS2R38 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_176817
• Synonyms: PTC; T2R38; T2R61
• Summary: 'This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]'