Human PTGS1 activation kit by CRISPRa

CAT#: GA103906

PTGS1 CRISPRa kit - CRISPR gene activation of human prostaglandin-endoperoxide synthase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTGS1
• Locus ID: 5742
• Kit Components:

  GA103906G1, PTGS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103906G2, PTGS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103906G3, PTGS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000962, NM_001271164, NM_001271165, NM_001271166, NM_001271367, NM_001271368, NM_080591
• Synonyms: COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
• Summary: 'This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'