Human Parathyroid Hormone Receptor 1 (PTH1R) activation kit by CRISPRa

CAT#: GA103909

PTH1R CRISPRa kit - CRISPR gene activation of human parathyroid hormone 1 receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTH1R
• Locus ID: 5745
• Kit Components:

  GA103909G1, Parathyroid Hormone Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103909G2, Parathyroid Hormone Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103909G3, Parathyroid Hormone Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000316, NM_001184744
• Synonyms: PFE; PTHR; PTHR1
• Summary: 'The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]'