Human Brk (PTK6) activation kit by CRISPRa

CAT#: GA103912

PTK6 CRISPRa kit - CRISPR gene activation of human protein tyrosine kinase 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTK6
• Locus ID: 5753
• Kit Components:

  GA103912G1, Brk gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103912G2, Brk gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103912G3, Brk gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256358, NM_005975
• Synonyms: BRK
• Summary: 'The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]'