Human TCPTP (PTPN2) activation kit by CRISPRa

CAT#: GA103920

PTPN2 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPN2
• Locus ID: 5771
• Kit Components:

  GA103920G1, TCPTP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103920G2, TCPTP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103920G3, TCPTP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001207013, NM_001308287, NM_002828, NM_080422, NM_080423
• Synonyms: PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]'