Human PTPN7 activation kit by CRISPRa

CAT#: GA103924

PTPN7 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPN7
• Locus ID: 5778
• Kit Components:

  GA103924G1, PTPN7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA103924G2, PTPN7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA103924G3, PTPN7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199797, NM_002832, NM_080588, NM_080589, NR_037663, NR_037664, NM_001364877, NM_001364878
• Synonyms: BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]