Human CD45 (PTPRC) activation kit by CRISPRa

CAT#: GA103932

PTPRC CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPRC
• Locus ID: 5788
• Kit Components:

  GA103932G1, CD45 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103932G2, CD45 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103932G3, CD45 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001267798, NM_002838, NM_080921, NM_080922, NM_080923, NR_052021
• Synonyms: B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]'