Human PTPRD activation kit by CRISPRa

CAT#: GA103933

PTPRD CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPRD
• Locus ID: 5789
• Kit Components:

  GA103933G1, PTPRD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103933G2, PTPRD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103933G3, PTPRD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040712, NM_001171025, NM_002839, NM_130391, NM_130392, NM_130393
• Synonyms: HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]'