Human PTP epsilon (PTPRE) activation kit by CRISPRa

CAT#: GA103935

PTPRE CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPRE
• Locus ID: 5791
• Kit Components:

  GA103935G1, PTP epsilon gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103935G2, PTP epsilon gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103935G3, PTP epsilon gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316676, NM_001316677, NM_006504, NM_130435, NM_001323354, NM_001323355, NM_001323356, NM_001323357
• Synonyms: HPTPE; PTPE; R-PTP-EPSILON
• Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]'