Human PURA activation kit by CRISPRa

CAT#: GA103952

PURA CRISPRa kit - CRISPR gene activation of human purine rich element binding protein A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PURA
• Locus ID: 5813
• Kit Components:

  GA103952G1, PURA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103952G2, PURA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103952G3, PURA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005859
• Synonyms: MRD31; PUR-ALPHA; PUR1; PURALPHA
• Summary: 'This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]'