Human Poliovirus Receptor (PVR) activation kit by CRISPRa

CAT#: GA103955

PVR CRISPRa kit - CRISPR gene activation of human PVR cell adhesion molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PVR
• Locus ID: 5817
• Kit Components:

  GA103955G1, Poliovirus Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103955G2, Poliovirus Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103955G3, Poliovirus Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135768, NM_001135769, NM_001135770, NM_006505
• Synonyms: CD155; HVED; Necl-5; NECL5; PVS; TAGE4
• Summary: 'The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]'