Human RAD51C activation kit by CRISPRa

CAT#: GA104002

RAD51C CRISPRa kit - CRISPR gene activation of human RAD51 paralog C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD51C
• Locus ID: 5889
• Kit Components:

  GA104002G1, RAD51C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104002G2, RAD51C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104002G3, RAD51C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002876, NM_058216, NM_058217, NR_103872, NR_103873
• Synonyms: BROVCA3; FANCO; R51H3; RAD51L2
• Summary: 'This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]'