Human RAD52 activation kit by CRISPRa

CAT#: GA104006

RAD52 CRISPRa kit - CRISPR gene activation of human RAD52 homolog, DNA repair protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD52
• Locus ID: 5893
• Kit Components:

  GA104006G1, RAD52 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104006G2, RAD52 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104006G3, RAD52 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001297419, NM_001297420, NM_001297421, NM_001297422, NM_002879, NM_134422, NM_134423, NM_134424, NR_123713
• Summary: 'The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]'