Human RbAp48 (RBBP4) activation kit by CRISPRa

CAT#: GA104038

RBBP4 CRISPRa kit - CRISPR gene activation of human RB binding protein 4, chromatin remodeling factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RBBP4
• Locus ID: 5928
• Kit Components:

  GA104038G1, RbAp48 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104038G2, RbAp48 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104038G3, RbAp48 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135255, NM_001135256, NM_005610
• Synonyms: lin-53; NURF55; RBAP48
• Summary: 'This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]'