Human NF-kB p65 (RELA) activation kit by CRISPRa

CAT#: GA104066

RELA CRISPRa kit - CRISPR gene activation of human RELA proto-oncogene, NF-kB subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RELA
• Locus ID: 5970
• Kit Components:

  GA104066G1, NF-kB p65 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104066G2, NF-kB p65 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104066G3, NF-kB p65 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145138, NM_001243984, NM_001243985, NM_021975
• Synonyms: NFKB3; p65
• Summary: 'NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]'