Human RFC1 activation kit by CRISPRa

CAT#: GA104075

RFC1 CRISPRa kit - CRISPR gene activation of human replication factor C subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RFC1
• Locus ID: 5981
• Kit Components:

  GA104075G1, RFC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104075G2, RFC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104075G3, RFC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204747, NM_002913, NM_001363495, NM_001363496
• Synonyms: A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
• Summary: 'This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]'