Human RFC2 activation kit by CRISPRa

CAT#: GA104076

RFC2 CRISPRa kit - CRISPR gene activation of human replication factor C subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RFC2
• Locus ID: 5982
• Kit Components:

  GA104076G1, RFC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104076G2, RFC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104076G3, RFC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278791, NM_001278792, NM_001278793, NM_002914, NM_181471
• Synonyms: RFC40
• Summary: 'This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]'