Human RFX1 activation kit by CRISPRa

CAT#: GA104083

RFX1 CRISPRa kit - CRISPR gene activation of human regulatory factor X1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RFX1
• Locus ID: 5989
• Kit Components:

  GA104083G1, RFX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104083G2, RFX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104083G3, RFX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002918
• Synonyms: EFC; RFX
• Summary: 'This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]'