Human Relaxin 1 (RLN1) activation kit by CRISPRa

CAT#: GA104105

RLN1 CRISPRa kit - CRISPR gene activation of human relaxin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RLN1
• Locus ID: 6013
• Kit Components:

  GA104105G1, Relaxin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104105G2, Relaxin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104105G3, Relaxin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006911
• Synonyms: bA12D24.3.1; bA12D24.3.2; H1; H1RLX; RLXH1
• Summary: 'Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]'