Human Relaxin 2 (RLN2) activation kit by CRISPRa

CAT#: GA104111

RLN2 CRISPRa kit - CRISPR gene activation of human relaxin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RLN2
• Locus ID: 6019
• Kit Components:

  GA104111G1, Relaxin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104111G2, Relaxin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104111G3, Relaxin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329191, NM_005059, NM_134441
• Synonyms: bA12D24.1.1; bA12D24.1.2; H2; H2-RLX; RLXH2
• Summary: 'This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]'