Human RNF4 activation kit by CRISPRa

CAT#: GA104120

RNF4 CRISPRa kit - CRISPR gene activation of human ring finger protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF4
• Locus ID: 6047
• Kit Components:

  GA104120G1, RNF4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104120G2, RNF4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104120G3, RNF4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185009, NM_001185010, NM_002938
• Synonyms: RES4-26; SLX5; SNURF
• Summary: 'The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]'