Human Ribonuclease Inhibitor (RNH1) activation kit by CRISPRa

CAT#: GA104123

RNH1 CRISPRa kit - CRISPR gene activation of human ribonuclease/angiogenin inhibitor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNH1
• Locus ID: 6050
• Kit Components:

  GA104123G1, Ribonuclease Inhibitor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104123G2, Ribonuclease Inhibitor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104123G3, Ribonuclease Inhibitor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002939, NM_203383, NM_203384, NM_203385, NM_203386, NM_203387, NM_203388, NM_203389
• Synonyms: RAI; RNH
• Summary: 'Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]'