Human ROR gamma (RORC) activation kit by CRISPRa

CAT#: GA104132

RORC CRISPRa kit - CRISPR gene activation of human RAR related orphan receptor C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RORC
• Locus ID: 6097
• Kit Components:

  GA104132G1, ROR gamma gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104132G2, ROR gamma gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104132G3, ROR gamma gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001523, NM_005060
• Synonyms: IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR
• Summary: 'The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'