Human Serum Amyloid A (SAA1) activation kit by CRISPRa

CAT#: GA104265

SAA1 CRISPRa kit - CRISPR gene activation of human serum amyloid A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SAA1
• Locus ID: 6288
• Kit Components:

  GA104265G1, Serum Amyloid A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104265G2, Serum Amyloid A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104265G3, Serum Amyloid A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000331, NM_001178006, NM_199161
• Synonyms: PIG4; SAA; SAA2; TP53I4
• Summary: 'This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Jul 2020]'