Human serum amyloid A2 (SAA2) activation kit by CRISPRa

CAT#: GA104266

SAA2 CRISPRa kit - CRISPR gene activation of human serum amyloid A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SAA2
• Locus ID: 6289
• Kit Components:

  GA104266G1, serum amyloid A2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104266G2, serum amyloid A2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104266G3, serum amyloid A2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127380, NM_030754
• Synonyms: serum amyloid A2
• Summary: 'This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020]'