Human SCN1B activation kit by CRISPRa

CAT#: GA104291

SCN1B CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel beta subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN1B
• Locus ID: 6324
• Kit Components:

  GA104291G1, SCN1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104291G2, SCN1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104291G3, SCN1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037, NM_199037, NM_001321605
• Synonyms: ATFB13; BRGDA5; GEFSP1
• Summary: 'Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]'