Human SCN4B activation kit by CRISPRa

CAT#: GA104296

SCN4B CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel beta subunit 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN4B
• Locus ID: 6330
• Kit Components:

  GA104296G1, SCN4B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104296G2, SCN4B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104296G3, SCN4B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142348, NM_001142349, NM_174934, NR_024527
• Synonyms: ATFB17; LQT10; Navbeta4
• Summary: 'The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]'