Human Nav1.6 (SCN8A) activation kit by CRISPRa

CAT#: GA104299

SCN8A CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel alpha subunit 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN8A
• Locus ID: 6334
• Kit Components:

  GA104299G1, Nav1.6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104299G2, Nav1.6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104299G3, Nav1.6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001177984, NM_014191, NM_001330260, NM_001369788
• Synonyms: CERIII; CIAT; EIEE13; MED; NaCh6; Nav1.6; PN4
• Summary: 'This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]'