Human I 309 (CCL1) activation kit by CRISPRa

CAT#: GA104311

CCL1 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine ligand 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCL1
• Locus ID: 6346
• Kit Components:

  GA104311G1, CCL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104311G2, CCL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104311G3, CCL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002981
• Synonyms: I-309; P500; SCYA1; SISe; TCA3
• Summary: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]