Human Syntenin (SDCBP) activation kit by CRISPRa

CAT#: GA104341

SDCBP CRISPRa kit - CRISPR gene activation of human syndecan binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDCBP
• Locus ID: 6386
• Kit Components:

  GA104341G1, Syntenin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104341G2, Syntenin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104341G3, Syntenin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007067, NM_001007068, NM_001007069, NM_001007070, NM_005625, NM_001330537, NM_001348339, NM_001348340, NM_001348341
• Synonyms: MDA-9; MDA9; ST1; SYCL; TACIP18
• Summary: 'The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]'