Human SDHB activation kit by CRISPRa

CAT#: GA104345

SDHB CRISPRa kit - CRISPR gene activation of human succinate dehydrogenase complex iron sulfur subunit B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDHB
• Locus ID: 6390
• Kit Components:

  GA104345G1, SDHB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104345G2, SDHB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104345G3, SDHB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003000
• Synonyms: CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
• Summary: 'Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]'