Human SDHC activation kit by CRISPRa

CAT#: GA104346

SDHC CRISPRa kit - CRISPR gene activation of human succinate dehydrogenase complex subunit C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SDHC
• Locus ID: 6391
• Kit Components:

  GA104346G1, SDHC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104346G2, SDHC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104346G3, SDHC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001035511, NM_001035512, NM_001035513, NM_001278172, NM_003001, NR_103459
• Synonyms: CYB560; CYBL; PGL3; QPS1; SDH3
• Summary: 'This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]'