Human CD62E (SELE) activation kit by CRISPRa

CAT#: GA104354

SELE CRISPRa kit - CRISPR gene activation of human selectin E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SELE
• Locus ID: 6401
• Kit Components:

  GA104354G1, CD62E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104354G2, CD62E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104354G3, CD62E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000450
• Synonyms: CD62E; ELAM; ELAM1; ESEL; LECAM2
• Summary: 'The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]'