Human CD162 (SELPLG) activation kit by CRISPRa

CAT#: GA104357

SELPLG CRISPRa kit - CRISPR gene activation of human selectin P ligand

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SELPLG
• Locus ID: 6404
• Kit Components:

  GA104357G1, CD162 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104357G2, CD162 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104357G3, CD162 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206609, NM_003006
• Synonyms: CD162; CLA; PSGL-1; PSGL1
• Summary: 'This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]'