Human SFRP1 activation kit by CRISPRa

CAT#: GA104367

SFRP1 CRISPRa kit - CRISPR gene activation of human secreted frizzled related protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SFRP1
• Locus ID: 6422
• Kit Components:

  GA104367G1, SFRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104367G2, SFRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104367G3, SFRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003012
• Synonyms: FRP; FRP-1; FRP1; FrzA; SARP2
• Summary: 'This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]'