Human SC35 (SRSF2) activation kit by CRISPRa

CAT#: GA104372

SRSF2 CRISPRa kit - CRISPR gene activation of human serine and arginine rich splicing factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SRSF2
• Locus ID: 6427
• Kit Components:

  GA104372G1, SC35 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104372G2, SC35 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104372G3, SC35 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195427, NM_003016, NR_036608
• Synonyms: PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b
• Summary: 'The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]'