Human SFTPC activation kit by CRISPRa

CAT#: GA104381

SFTPC CRISPRa kit - CRISPR gene activation of human surfactant protein C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SFTPC
• Locus ID: 6440
• Kit Components:

  GA104381G1, SFTPC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104381G2, SFTPC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104381G3, SFTPC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172357, NM_001172410, NM_001317778, NM_001317779, NM_001317780, NM_003018
• Synonyms: BRICD6; PSP-C; SFTP2; SMDP2; SP-C
• Summary: 'This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]'