Human SGK1 activation kit by CRISPRa

CAT#: GA104387

SGK1 CRISPRa kit - CRISPR gene activation of human serum/glucocorticoid regulated kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SGK1
• Locus ID: 6446
• Kit Components:

  GA104387G1, SGK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104387G2, SGK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104387G3, SGK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143676, NM_001143677, NM_001143678, NM_001291995, NM_005627
• Synonyms: SGK
• Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]