Human Secretogranin V (SCG5) activation kit by CRISPRa

CAT#: GA104388

SCG5 CRISPRa kit - CRISPR gene activation of human secretogranin V

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCG5
• Locus ID: 6447
• Kit Components:

  GA104388G1, Secretogranin V gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104388G2, Secretogranin V gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104388G3, Secretogranin V gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144757, NM_003020
• Synonyms: 7B2; P7B2; SGNE1; SgV
• Summary: 'This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]'