Human SH3BP2 activation kit by CRISPRa

CAT#: GA104393

SH3BP2 CRISPRa kit - CRISPR gene activation of human SH3 domain binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH3BP2
• Locus ID: 6452
• Kit Components:

  GA104393G1, SH3BP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104393G2, SH3BP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104393G3, SH3BP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001122681, NM_001145855, NM_001145856, NM_003023
• Synonyms: 3BP-2; 3BP2; CRBM; CRPM; RES4-23
• Summary: 'The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]'