Human SH3 containing Grb 2 like 1 protein (SH3GL1) activation kit by CRISPRa

CAT#: GA104395

SH3GL1 CRISPRa kit - CRISPR gene activation of human SH3 domain containing GRB2 like 1, endophilin A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH3GL1
• Locus ID: 6455
• Kit Components:

  GA104395G1, SH3 containing Grb 2 like 1 protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104395G2, SH3 containing Grb 2 like 1 protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104395G3, SH3 containing Grb 2 like 1 protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199943, NM_001199944, NM_003025
• Synonyms: CNSA1; EEN; SH3D2B; SH3P8
• Summary: 'This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]'