Human SHMT2 activation kit by CRISPRa

CAT#: GA104404

SHMT2 CRISPRa kit - CRISPR gene activation of human serine hydroxymethyltransferase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SHMT2
• Locus ID: 6472
• Kit Components:

  GA104404G1, SHMT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104404G2, SHMT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104404G3, SHMT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166356, NM_001166357, NM_001166358, NM_001166359, NM_005412, NR_029415, NR_029416, NR_029417, NR_048562
• Synonyms: GLYA; HEL-S-51e; SHMT
• Summary: 'This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]'