Human SHOX2 activation kit by CRISPRa

CAT#: GA104406

SHOX2 CRISPRa kit - CRISPR gene activation of human short stature homeobox 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SHOX2
• Locus ID: 6474
• Kit Components:

  GA104406G1, SHOX2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104406G2, SHOX2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104406G3, SHOX2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163678, NM_003030, NM_006884
• Synonyms: OG12; OG12X; SHOT
• Summary: This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]