Human SnoN (SKIL) activation kit by CRISPRa

CAT#: GA104424

SKIL CRISPRa kit - CRISPR gene activation of human SKI like proto-oncogene

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SKIL
• Locus ID: 6498
• Kit Components:

  GA104424G1, SnoN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104424G2, SnoN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104424G3, SnoN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145097, NM_001145098, NM_001248008, NM_005414
• Synonyms: SNO; SnoA; SnoI; SnoN
• Summary: 'The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]'