Human VMAT1 (SLC18A1) activation kit by CRISPRa

CAT#: GA104489

SLC18A1 CRISPRa kit - CRISPR gene activation of human solute carrier family 18 member A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC18A1
• Locus ID: 6570
• Kit Components:

  GA104489G1, VMAT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104489G2, VMAT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104489G3, VMAT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135691, NM_001142324, NM_001142325, NM_003053
• Synonyms: CGAT; VAT1; VMAT1
• Summary: 'The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]'