Human SNF5 (SMARCB1) activation kit by CRISPRa

CAT#: GA104512

SMARCB1 CRISPRa kit - CRISPR gene activation of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SMARCB1
• Locus ID: 6598
• Kit Components:

  GA104512G1, SNF5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104512G2, SNF5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104512G3, SNF5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007468, NM_001317946, NM_003073, NM_001362877
• Synonyms: BAF47; CSS3; hSNFS; INI1; MRD15; PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1
• Summary: 'The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]'