Human Sorbitol Dehydrogenase (SORD) activation kit by CRISPRa

CAT#: GA104562

SORD CRISPRa kit - CRISPR gene activation of human sorbitol dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SORD
• Locus ID: 6652
• Kit Components:

  GA104562G1, Sorbitol Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104562G2, Sorbitol Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104562G3, Sorbitol Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003104, NR_034039
• Synonyms: HEL-S-95n; SORD1
• Summary: 'Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]'